It is indeed amazing the amount of anti-aging research that is going on.” That’s the opening line of the previous issue. I repeat because it is so appropriate to this issue. The headline says “New” and it is new to me, and in terms of how long it takes new medical discoveries to reach and/or be considered by physicians — remember the 57 years to accept the easy solution for morning sickness during pregnancy – it is very new.
The 2009 Nobel Prize in Medicine was awarded to three Americans in October of that year. Well, the discovery was not quite that new. It was back in the 1970’s they discovered that the part of the chromosome that is at its end is not a useless, dysfunctional tail as previously believed by scientists around the world, but is actually an important part of your DNA. It seems that this part, named the telomere, is critical for healthy cell division as well as healthy cell function. The telomere is the part of the chromosome where the DNA enzymes attach in order to activate function of the genes. In turn, this leads to making proteins and more enzymes.
Cells are constantly being replaced by cell division where the new cell is the exact copy of the old one it is replacing. You can see that this process must be perfect and is closely related to aging. DNA is the coil where the overall plan for your body is recorded in exquisite detail and it is in every one of the trillion cells of the body!
The problem is that the telomeres of the new cells get shorter and shorter each time the cells divide. When they become too short, the chromosomes can not function and the DNA becomes useless. You start with long telomeres. As the years go by, increasing numbers of cells die that are not properly replaced because their telomeres have become too short. This process manifests as aging.
It appears from that explanation that there could be no remedy for aging, but that isn’t the whole story by any means.
First, there is a special enzyme called telomerase that can actually restore telomeres! Both reproductive cells and stem cells have telomerase. Unfortunately, so do cancer cells, which can divide indefinitely. If we can find a way to activate telomerase with our healthy cells, it will keep us more youthful and simultaneously ward off cancer. Factors against us in this are toxins, stress, bad nutrition, and anything that causes higher levels of homocysteine, which seems to inactivate telomerase. (Homocysteine is an amino acid in the blood. Studies have shown that too much homocysteine in the blood (plasma) is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease. )
Homocysteine can easily be lowered with vitamins B12, B6 and folate (many medical professionals and writers assume that folic acid is the same as the vitamin folate, but folic acid is an oxidized form that may accelerate cognitive decline in some older folk and that has been linked to increased risk of colon and rectal cancer. No such risks are attached to naturally occurring folates, found in leafy and green vegetables such as spinach, lettuce, broccoli, Brussels sprouts, etc.
Not only good diet but also certain supplements can enhance telomerase activity. Green tea supports longer telomeres. Drink three cups a day and add years to the length of your telomeres and therefore to your life expectancy. The same can be said for vitamin D3, which has become very popular lately as more experts realize how many benefits it has and how small the recommended dosage has been. Superoxide dismutase is a critically important antioxidant enzyme that is made by the body but can also be taken as a supplement. Higher levels slow telomere shortening.
Now let’s consider a closely related subject where a new discovery offers unprecedented control over destructive aging processes. The discovery is a new compound that promotes the growth of new mitochondria. Mitochondria are vital bacteria that live inside our cells. They are the cellular power plants that provide 95% of our cellular energy.
If cells are damaged by trauma or by aging pathology, mitochondria may be released from dying tissue. Our immune system sees them as foreign bacteria and responds with inflammation that, if acute, can be fatal, as seen in sepsis, or if chronic, will slowly attack every living tissue. (This demonstrates the importance of long term daily use of Catherine’s Choice Aloe Vera, a mild but powerful anti-inflammatory.)
Mitochondria in healthy cells with intact cell walls that shield them from the immune system do not trigger inflammatory response. Normally these energy producing bacteria have a symbiotic relationship that is very healthy and mutually beneficial as long as the mitochondria is well nourished and protected by nutrients like CoQ10, L-carnitine and, I venture to suggest, aloe vera.
It is vital to maintain youthful mitochondrial function and structure. In a recent study, researchers found that muscle tissue of a man aged 90 contained 95% damaged mitochondria compared to almost no damage in that of a 5-year-old. Mitochondrial dysfunction is a primary cause of age-related decline!
Damaged or insufficient mitochondria can have a horrible effect. A plethora of recent scientific reports link defective and deficient mitochondria to virtually all degenerative diseases including diabetes, cancer, heart failure, and even Alzheimer’s!
As suggested above, up to now we could protect and improve the function of existing mitochondria with our best nutrients, but the only way to stimulate creation of additional, new mitochondria was reduction of calories or exhaustive physical activity. But now there is the new discovery I mentioned before. It is a natural agent with the power to safely induce mitochondrial biogenesis!
Mitochondrial biogenesis IS the creation of additional, new mitochondria.
The name of this remarkable substance is pyrroloquinoline quinone, but we will call it by its initials, PQQ. It may well be able to at least halt and hopefully even reverse cellular aging! It is present in all plant species tested and is present in human milk, but is not synthesized by the human body. It is therefore classified as an essential micronutrient.
Notice above statement that “it is present in all plant species tested.” I learned that just as I copied it from my source a moment ago. Immediately I realized that aloe vera is well known for essential micronutrients. I do not know that it has been tested for this particular one (PQQ), but that may well be the explanation for my being the Young Octogenarian! Whether it is or not, I know that you should always make your choice Catherine’s Choice for better health!
Warren, the Young Octogenarian












